Prostate Metastasis in Renal Cell Carcinoma: Rare Occurrence and Clinical Insights.

Abstract

Renal cell carcinoma (RCC), with clear cell RCC being the predominant subtype, is a leading urogenital malignancy with a propensity for systemic dissemination. However, prostate metastasis remains extremely rare, with only 12 documented cases. This review synthesises clinical, pathological, and molecular insights into RCC prostate metastases, highlighting diagnostic challenges and therapeutic implications. However, the specific drivers of prostate seeding remain uncharacterised. The main therapeutic strategies are cytoreductive nephrectomy, metastasectomy, and stereotactic body radiation therapy, with multimodal approaches demonstrating survival benefits in oligometastatic cases. Despite these advances, the prognosis remains poor, particularly for patients with non-isolated metastases, highlighting the need for multidisciplinary management. Current evidence highlights the clinical relevance of urogenital surveillance and tailored strategies, although standardised protocols remain lacking. This synthesis advocates the integration of molecular profiling, advanced imaging, and multidisciplinary frameworks to refine risk stratification and optimise outcomes for this rare metastatic phenotype. Key Words: Renal cell carcinoma, Prostate metastasis, Oligometastasis, Multidisciplinary management, Molecular biomarkers.

Abstract as supplied by the indexing source. © the authors / publisher.