One new polyketide, diaporone B, isolated from the endophytic fungus Diaporthe discoidispora MQZ-Z1 and its antifungal activity.

Abstract

One previously undescribed polyketide, diaporone B (1), along with four known polyketides (2-5), was isolated from the endophytic fungus Diaporthe discoidispora MQZ-Z1, which was derived from the leaves of Strychnos nux-vomica L. Their chemical structures were elucidated by HRESIMS, 1D and 2D NMR spectroscopy. Compounds 1-5 were evaluated for their fungistatic activity against Candida albicans CMCC 98001 and Aspergillus niger R330. Among them, compound 2 showed antifungal activity against C. albicans with an MIC value of 12.5 μg/mL.

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