Natural Polymer-Based Mucoadhesive Patches for Cancer Therapy: Current Advances and Future Perspectives.

Abstract

OBJECTIVE: The aim of the review is to discuss about natural polymer-based mucoadhesive patches for localized drug delivery in cancer therapy. It explains the various formulation techniques used in patch formulation, along with the principle and mechanism of mucoadhesion, evaluation parameters, and therapeutic uses in cancer. The available preclinical evidence is critically evaluated for benefits, limitations, translation challenges, and stronger evidence of therapeutic efficacy and safety in the recent literature prior to 2026. SIGNIFICANCE: Mucoadhesive Drug Delivery Systems (MDDS) uses mucoadhesive polymer that adhere to the mucosal wall and provide prolonged release of the drug, which results in higher bioavailability, and decreased hepatic first pass metabolism. Among the various dosage forms, the MDDS Patch gives close contact with the mucosa because they are able to interact with each other via various types of bonds, and polymer chain interpenetration. According to various literature surveys, natural polymers are biocompatible and biodegradable and exhibit excellent mucoadhesive properties, which can be exploited to create flexible patches to suit patient needs. KEY FINDINGS: The work incorporated in this review shows that natural polymers used to formulate mucoadhesive patches can deliver extended drug release, increase drug bioavailability, improve therapeutic efficacy, and enable focused drug delivery with enhanced patient compliance. CONCLUSIONS: Polymer-based mucoadhesive patches based on natural polymers are promising vehicles in localized drug delivery to treat cancer, which may offer an extended residence time, sustained drug delivery and availability in the local site.

Abstract as supplied by the indexing source. © the authors / publisher.