Synthesis of 2,4-diphenylthiophene derivatives via the cleavage of C-C/C-H bonds and metal-free sulfuration/annulation of alkenes.

Abstract

A metal-free annulation strategy for the synthesis of 2,4-diphenylthiophene derivatives via C-C/C-H bond cleavage and C-S bond formation between bis(ester)-functionalized 2-phenyl-2-(2-phenylallyl)malonate and K2S·5H2O is described. A broad range of substrates with various substituents installed at the ortho-, meta- and para-positions of the aromatic ring could react smoothly, delivering the corresponding products in up to 92% yield.

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