A metallacycle-couple-close approach to fused polycyclic frameworks: synthesis of the proposed structure of a stilbene-phenylpropanoid natural product.

Abstract

Metallacycle-mediated annulations largely rely on insertion pathways. We report a metallacycle-couple-close strategy enabling rapid polycycle synthesis through distinct reactivity modes. Total synthesis of proposed structure 10 and NMR comparisons suggest trans-fused structure 24 for a stilbene-phenylpropanoid natural product, pending direct synthetic verification.

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