A new high-performance electrochemical sensor fabricated by metal-organic framework/Ketjen black composite for sensitive detection of chlorogenic acid in food and blood serum.

Abstract

Chlorogenic acid (CGA) is widely present in foods such as coffee and tea. Excessive intake of CGA may have adverse effects on human health. Therefore, its rapid and sensitive detection is crucial for food quality control. This paper reports a novel metal-organic framework (MOF) [CdCl2(L)0.5]∙0.5DMF∙H2O (1) (DMF = N, N-dimethylformamide) assembled from a thiacalix[4]arene ligand (L) substituted with methylimidazole and Cd(II) cations. A series of electrode modification materials were constructed by mechanically grinding 1 and Ketjen black (KB). Under optimized conditions, 1/KB(1:1)@GCE (GCE = glassy carbon electrode) exhibited excellent electrocatalytic activity towards CGA. Furthermore, the sensor exhibited a low limit of detection (LOD) of 0.2 nM for CGA. Specifically, the sensor was successfully applied to the determination of CGA in food samples and serum, with a recovery rate of 97.21-103.83%, demonstrating its feasibility in food quality monitoring and practical bioanalytical applications. Notably, the quantitative analysis of CGA in mung bean sprout culture medium further confirmed its strong anti-interference capability in complex biological matrices. This study provides an analytical platform for the rapid determination of CGA in foods.

Abstract as supplied by the indexing source. © the authors / publisher.