Pd-catalyzed oxo-sulfonylation of methylenecyclopropanes for the synthesis of cyclopropanyl β-ketosulfones.

Abstract

Pd-catalyzed oxo-sulfonylation of methylenecyclopropanes with sulfinic acids was developed to produce a series of cyclopropyl β-ketosulfones in good yields. This protocol features broad substrate compatibility, mild reaction conditions and an environmentally benign oxygen source. Mechanistic investigations revealed a cascade radical pathway for the catalytic process.

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