Generation and utilization of sulfonyl radicals and N-centered radicals in the synthesis of β-amino sulfones.

Abstract

β-Amino sulfone motifs are widely present in natural active molecules, drugs, and agro-chemicals, and have shown great potential in clinical applications. In this article, we systematically summarize the generation and application of sulfonyl radicals and N-centered radicals in the synthesis of β-amino sulfones from 2020 to the present. We focus on the pathways of generation of sulfonyl radicals and N-centered radicals and analyze in detail their key roles in the construction of β-amino sulfones. Therefore, we have divided this article into three parts for discussion: (i) visible-light catalysis, (ii) transition-metal oxidation or catalysis, and (iii) transition-metal-free radical reactions.

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