Coinage Metals Mediated Skeletal Functionalizations of Coumarin and Chromones: Recent Advances and Mechanistic Aspect.

Abstract

Chromone and coumarin are privileged scaffolds that are extensively found in natural products, synthetic intermediates, pharmaceutical compounds, and functional materials. These frameworks possess multiple C─H bonds that can be selectively functionalized into valuable molecules, facilitating the synthesis of a broad range of compounds with diverse pharmacological properties. Given the significance of functionalized chromone and coumarin derivatives and the notable progress in their synthesis through direct C─H activation or functionalization and several organic transformations, this review focuses on recent advancements in the coinage metal-catalyzed, efficient, and site-selective C─H bond functionalization and skeletal functionalization of these structural frameworks.

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