Lysozyme Hydrogel Microneedles for Enhanced Burn Wound Healing.

Abstract

To reduce the inconvenience of medication for patients during burn wound healing, developing a novel drug delivery system is highly significant. In this study, we developed lysozyme-loaded hydrogel microneedles incorporating methacrylated hyaluronic acid (HAMA) into the needle matrix. We observed the morphological structure of the microneedles using a stereomicroscope and a scanning electron microscope, and characterized the materials by means of X-ray diffraction (XRD), infrared spectroscopy and Differential scanning calorimetry (DSC). Furthermore, the in vitro release and in vitro antibacterial ability of the lysozyme hydrogel microneedles were studied. Finally, the application of these microneedles in the healing of animal burn wounds was carried out. Upon subcutaneous application, the hydrogel interacts with the tissue and gradually releases lysozyme. Compared with traditional topical application drug delivery, these microneedles demonstrate higher subcutaneous penetration efficiency and a sustained-release profile. In vivo experiments on burn wound healing further confirmed that the lysozyme hydrogel microneedles significantly enhance the healing process. The designed microneedles are both convenient and efficient, offering a promising new approach for burn wound treatment.

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