Catalyst-free three-component synthesis of 3-aminoalkyl chromones with o-hydroxyaryl enaminones, rongalite and amines.

Abstract

A practical method for the synthesis of 3-aminomethylene-functionalized chromones has been developed using o-hydroxyaryl enaminones, amines and rongalite as starting materials. The reactions are conducted under mild heating in the green medium ethyl lactate (EL), without the use of any additional catalyst or promoter. This method enables the synthesis of the target chromone scaffolds with broad scope, including the N-functionalization of amino acids, generally affording good-to-excellent yields in the three-component reaction mode.

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