4-[(4-Fluoro-phen-yl)amino]-5-(2-meth-oxy-phen-yl)-8,8-dimethyl-6,7,8,9-tetra-hydro-5H-chromeno[2,3-d]pyrimidin-6-one.

Abstract

The asymmetric unit of the title compound, C26H24FN3O3, contains one mol-ecule comprising a tricyclic chromeno[2,3-d]pyrimidine core formed by fused cyclo-hexa-none, pyran and pyrimidine rings. The sp 3-hybridized methine carbon atom bears a 2-meth-oxy-phenyl substituent, which is oriented almost perpendicular to the pyran ring, with a dihedral angle of 84.11 (5)°. The 4-fluoro-phenyl-amino substituent is twisted relative to the pyrimidine ring, as indicated by the C-C-N-C torsion angle of 29.79 (18)° and the dihedral angle of 27.59 (4)° In the crystal, C-H⋯O and C-H⋯F hydrogen bonds link the mol-ecules into supra-molecular chains extending diagonally within the ac plane. An intra-molecular N-H⋯O hydrogen bond is also present between the amino and meth-oxy groups.

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