Top 10 · Tuesday, 10 November 2026

Changes in bile acids (BAs) balance lead to various metabolic diseases, yet current treatment options targeting these changes remain severely limited. CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) is a liver-exclusive enzyme that controls the synthesis of 12α-hydroxylated (12α-OH) BAs. Inhibiting CYP8B1 is an attractive therapeutic strategy for attenuating 12α-OH BA levels, remodeling the gut microbiota and thereby… Read full abstract

New-to-nature radical biocatalysis has emerged as a powerful strategy for asymmetric C-C bond formation, yet the enzyme-bound radical intermediates that underpin these transformations have remained largely uncharacterized. Here, we combine photobiocatalytic reaction development with multifrequency electron paramagnetic resonance (EPR), electron-nuclear double resonance (ENDOR) spectros-copy, and density functional theory (DFT) calculations to elucidate the ketyl radical intermediates formed during thiamine pyrophosphate… Read full abstract

Electrochemical CO2 reduction (CO2RR) converts renewable electricity into fuels and chemicals, but experimental chemists still struggle to track the structural evolution of CO2RR catalysts under reaction conditions and systematically optimize intertwined factors governing performance. However, interface dynamics under bias and reaction networks are complex, data are scattered across techniques and papers, and many catalyst "design rules" remain qualitative. Herein, we… Read full abstract

CONTEXT: First-principles density functional theory (DFT) calculations were performed to investigate the electronic, optical, and thermodynamic properties of a ZnO monolayer under hydrostatic pressures ranging from 0 to 40 GPa. The values of bond lengths, energy band gap, and dielectric constant were deduced for the first time using the theoretical plasmon calculations, show good agreement with the computed and reported… Read full abstract

The crystal structure of tri-methyl-ammonium manganese(II) chloride dihydrate or catena-poly[tri-methyl-ammonium [[di-aqua-manganese(II)]-di-μ-chlorido] chloride], {[(CH3)3NH][MnCl2(H2O)2]Cl} n (1), originally reported by Caputo et al. (1976 ▸). Acta Cryst. B32, 2639-2642], has been redetermined at 100 K. The structure retains the ortho-rhom-bic space group Pnma and the coordination connectivity of the previously reported room-temperature structure. Each MnII ion lies on an inversion centre and… Read full abstract

BACKGROUND: Tobacco smoking is the largest modifiable contributor to cardiovascular disease (CVD), yet population-level surveillance still relies on self-reported and retail data, which are subject to measuring bias and lag. Urinary and salivary cotinine quantify individual tobacco exposure, but no analogous, objective metric exists at the community level. Wastewater-based epidemiology (WBE) has transformed surveillance of infectious diseases and illicit drug… Read full abstract

BACKGROUND: Metabolic plasticity contributes to therapeutic resistance in T-cell lymphoma, but the metabolic dependencies underlying tyrosine kinase inhibitor (TKI) resistance remain poorly understood. ATP citrate lyase (ACLY), which converts citrate to cytosolic acetyl-CoA, links glucose metabolism to lipogenesis and acetylation-dependent regulation. We hypothesized that ACLY represents an actionable metabolic vulnerability in lymphoma. METHODS: Structure-guided drug discovery and biochemical screening were… Read full abstract

Cerium oxide nanoparticles (CeO₂ NPs) have attracted considerable interest because of their redox-related antioxidant properties, while surface modification with chitosan may alter their physicochemical and biological behavior. However, the balance between antioxidant activity and hemocompatibility following chitosan association remains insufficiently characterized. In this study, CeO₂ NPs were synthesized using a chemical precipitation method and subsequently associated with chitosan. The physicochemical… Read full abstract

Lanthanide nanoparticles (LnNPs) are photostable second near-infrared window (NIR-II) emitters well suited to long-term redox imaging. However, responsive LnNP nanoprobes generally require surface-installed molecular recognition components to transduce chemical changes into luminescence signals, which may introduce additional functionalization complexity and compromise long-term signal reliability. Here, we identify a redox-regulated phonon-assisted cooperative quenching (PACQ) phenomenon in NaCeF4:Nd, where Ce(III)/Ce(IV) conversion modulates… Read full abstract

A series of new Cu(II) phosphonopropionate coordination polymers (CPs) was obtained from reaction of CuCl2 and H3PPA (3-phosphonopropionic acid) in water under reflux conditions at different pH values (2, 3, 4, and 6). The resulting compounds, formulated as [Cu(μ4-HPPA)(μ-H2O)]n (Cu@pH2), [Cu(μ4-HPPA)(H2O)]n (Cu@pH3), [Cu(μ5-HPPA)]n (Cu@pH4), and [Cu2(PPA)(OH)]n·3nH2O (Cu@pH6), were isolated as stable microcrystalline solids and fully characterized. The crystal structures of… Read full abstract